The Curious Case of Oliver Sacks

9 July 1933 - birthday of Oliver Wolf Sacks, a British neurologist, naturalist, historian of science, and author. He believed that the brain is the "most incredible thing in the universe." He became widely known for writing best-selling case histories about both his patients' and his own disorders and unusual experiences.

He noted in a 2001 interview that severe shyness—which he described as "a disease"—had been a lifelong impediment to his personal interactions. Sacks believed his shyness stemmed from his prosopagnosia, popularly known as "face blindness", a condition that, coincidentally, he also studied in some of his patients, including the titular man from his work The Man Who Mistook His Wife for a Hat. This neurological disability of his even prevented him from recognising his own reflection in mirrors. Sacks' eldest brother Marcus also had prosopagnosia.

Prosopagnosia is a cognitive disorder of face perception in which the ability to recognise familiar faces, including one's own face (self-recognition), is impaired, while other aspects of visual processing (e.g., object discrimination) and intellectual functioning (e.g., decision making) remain intact.

Medial surface of left cerebral hemisphere. (Fusiform gyrus shown in orange)

The specific brain area usually associated with prosopagnosia is the fusiform gyrus, which activates specifically in response to faces. The functionality of the fusiform gyrus allows most people to recognise faces in more detail than they do similarly complex inanimate objects. The right hemisphere fusiform gyrus is more often involved in familiar face recognition than the left. It remains unclear whether the fusiform gyrus is only specific for the recognition of human faces or if it is also involved in highly trained visual stimuli.

Reference - Wikipedia

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Can our brain have a traffic jam?

The brain is an incredible processor, but is it possible to overload it?

In the average, healthy individual, the brain is an incredible piece of machinery capable of keeping the heart pumping, performing complex mental tasks and even allowing you to walk and chew gum, all at the same time. To a large degree, the brain is able to avoid traffic jams and keep all of these things happening at once with ease. To avoid interference between different parts of the brain, various regions operate on different frequencies.

For example, our hippocampus sends signals at around 5 hertz, while brain areas related to movement operate at 32 to 45 hertz. Think of it like the layers on an exit ramp. Signals sent at one frequency might travel on a different layer than those at another frequency, so these signals can avoid collision. These frequency differences allow different parts of the brain to operate all at once without interrupting one another or misinterpreting signals meant for other brain areas.

Despite this high level of sophistication, it's not a perfect system. After all, there has to be one mechanism responsible for initiating all those signals before they can travel through the brain. Some scientists refer to this mechanism as a "router" of sorts, which takes in information and sends signals throughout the brain. These signals don't bump into others thanks to frequency differences, but the router itself can suffer from overload if it receives signals too close together.

Right after a signal is received, the brain experiences a refractory period where it needs to reset itself in order to receive and process the next signal. If information is received during this refractory period, it can be missed or misprocessed because the brain's router is otherwise occupied.

The brain can also experience miniature traffic jams thanks to blockages along the paths that neurons take as they carry signals through the brain. Researchers discovered that fruit flies experience small, benign blockages on these neural pathways, which block brain signals, causing a traffic jam that can last for up to 30 seconds. Most of the time, these road blocks go away on their own, but some can remain permanently, interfering with communication between different parts of the brain. Further research on these traffic jams may help scientists treat serious neurological conditions, such as Alzheimer's.

Source - HowStuffWorks.com - Can your brain have a traffic jam? published by Bambi Turner on 12 March 2015